Designing biological systems.

Apoptosis and Self-Destruct: A Contribution to Autonomic Agents?

Autonomic Computing (AC), a self-managing systems initiative based on the biological metaphor of the autonomic nervous system, is increasingly gaining momentum as the way forward in designing reliable systems. Agent technologies have been identiiied as a key enabler for engineering autonomicity in systems, both in terms of retrofitting autonomicity into legacy systems and designing new systems....

Behavioral Considerations in Developing Web Information Systems: User-centered Design Agenda

The current paper explores designing a web information retrieval system regarding the searching behavior of users in real and everyday life. Designing an information system that is closely linked to human behavior is equally important for providers and the end users.  From an Information Science point of view, four approaches in designing information retrieval systems were identified as system-...

Knowledge Extraction and Annotation for Cross-Domain Textual Case-Based Reasoning in Biologically Inspired Design

Biologically inspired design (BID) is a methodology for designing technological systems by analogy to designs of biological systems. Given that knowledge of many biological systems is available mostly in the form of textual documents, the question becomes how can we extract design knowledge about biological systems from textual documents for potential use in designing engineering systems? In ea...

Key Issues in Designing Long-term Care Systems: A Response to Recent Commentaries

Using Tracking Differentiators in Designing Nonlinear Disturbance Observers for Uncertain Systems

Using Tracking Differentiators in Designing Nonlinear Disturbance Observers for Uncertain SystemsNaser Kazemzadeh, Saeed BarghandanAbstractIn the present paper, a practical designing method has been proposed for a novel class of NDOs based on TD. Such NDOs can nearly estimate all uncertain disturbances (specifically disturbances without prediction information). Regarding the outstanding perform...

Harnessing nature's toolbox: regulatory elements for synthetic biology.

Synthetic biologists seek to engineer complex biological systems composed of modular elements. Achieving higher complexity in engineered biological organisms will require manipulating numerous systems of biological regulation: transcription; RNA interactions; protein signalling; and metabolic fluxes, among others. Exploiting the natural modularity at each level of biological regulation will pro...